Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane
Constance Sat Lin Liew,
T. Kumaravadivel Dharmalingam,
Nik Abdullah Nik Mohamad
Issue:
Volume 4, Issue 2, March 2016
Pages:
5-10
Received:
28 April 2016
Accepted:
10 May 2016
Published:
13 June 2016
Abstract: This research was conducted considering the fact that today, there are still very few studies comparing Sevoflurane or Target Controlled Infusion using Propofol in term of serum lactate accumulation during general anaesthesia. There were 92 patients aged 18-65 years old, classified under ASA I, were involved in this prospective study. They were divided into 2 groups and this study was done in a double-blind manner. Patients received either Sevoflurane inhalational or Propofol infusion using Marsh model (target plasma concentration of 5 mcg/ml) during operation. All the patients received anaesthesia in a standard practice and blood samples were taken at every hour until completion of operation. The blood samples were tested for acid-base values and lactate level. There are significant differences in the mean values of serum lactate levels at 1st, 2nd, 3rd and 4th hour of surgery within propofol and sevoflurane group with p value of < 0.05. Nevertheless, when comparing differences in the mean values of serum lactate levels between propofol and sevoflurane group showed no significant difference of serum lactate change with p=0.186. In conclusion, our study shows that short term anaesthesia with sevoflurane is associated with an increase blood lactate levels more than lactate levels observed during high dose propofol anaesthesia.
Abstract: This research was conducted considering the fact that today, there are still very few studies comparing Sevoflurane or Target Controlled Infusion using Propofol in term of serum lactate accumulation during general anaesthesia. There were 92 patients aged 18-65 years old, classified under ASA I, were involved in this prospective study. They were div...
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